姓名：趙平

職務(wù)/職稱：副教授

E-mail：p.zhao@scuec.edu.cn

一、學(xué)習(xí)及工作經(jīng)歷

2010.7-至今，中南民族大學(xué)生命科學(xué)學(xué)院，副教授，碩士生導(dǎo)師

2006.11-2010.7，澳大利亞，新南威爾士大學(xué)，Garvan醫(yī)學(xué)研究所，博士后

2001.09-2006.07，華中科技大學(xué)生物物理學(xué)專業(yè)，博士

二、主要社會(huì)兼職

湖北省生理學(xué)會(huì)理事，武漢市生理學(xué)會(huì)理事

三、科研活動(dòng)及成果

（一）主要研究方向

糖尿病藥物篩選及機(jī)理研究

（二）主持的科研項(xiàng)目

國(guó)家自然科學(xué)基金面上項(xiàng)目2項(xiàng)。湖北省自然科學(xué)基金項(xiàng)目1項(xiàng)。中央高校基本科研業(yè)務(wù)費(fèi)專項(xiàng)基金項(xiàng)目5項(xiàng)。橫向課題3項(xiàng)。

（三）代表性論文

1. Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang*, Ping Zhao*. Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation. Food Science and Human Wellness. 12 (2023) 2040-2051.

2. Yanhong Yao#, Xinzhou Yang, Jinhua Shen and Ping Zhao*. Glucose Uptake Is Increased by Estradiol Dipropionate in L6 Skeletal Muscle Cells. Pharmaceuticals. 2023, 16, 25.

3. Jingya Liao# , Ziwei Yang# , Yanhong Yao , Xinzhou Yang , Jinhua Shen and Ping Zhao*. Andrographolide Promotes Uptake of Glucose and GLUT4 Transport through the PKC Pathway in L6 Cells. Pharmaceuticals. 2022, 15, 1346.

4. Guanjun Song^#, Yun Huang^#, Mingrui Xiong, Ziwei Yang, Qinghua Liu, Jinhua Shen1, Ping Zhao* and Xinzhou Yang* Aloperine Relieves Type 2 Diabetes Mellitus via Enhancing GLUT4 Expression and Translocation. Frontiers in Pharmacology. 25 January 2021. Volume 11, Article 561956.

5. Yibing Lv^#, Ping Zhao^#, Kejian Pang, Yuanren Ma, Huiqi Huang, Tongxi Zhou, Xinzhou Yang*. Antidiabetic effect of a flavonoid-rich extract from Sophora alopecuroides L. in HFD- and STZ- induced diabetic mice through PKC/GLUT4 pathway and regulating PPARα and PPARγ expression. Journal of Ethnopharmacology. 2021 Mar 25;268:113654.

6. Ping Zhao^#,*, Liu Jia ^#, Qian Ming, Di Tian, Jingwen He, Ziwei Yang, Jinhua Shen, Qing-Hua Liu, Xinzhou Yang^*. Dandelion Extract Relaxes Mouse Airway Smooth Muscle via the Blockade of VDLCC and NSCC Channels. Cell & Bioscience. 2020, 10: 125.

7. Ping Zhao ^#,*, Di Tian ^#, Guanjun Song, Qian Ming, Jia Liu, Jinhua Shen, Qing-Hua Liu and Xinzhou Yang^*. Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells. Frontiers in Pharmacology. 04 September 2019,10: 999.

8. Lv YB^#, Ming Q, Hao J, Huang Y, Chen H, Wang Q, Yang XZ^*, Zhao Ping^*. Anti-diabetic activity of canophyllol from Cratoxylum cochinchinense (Lour.) Blume in type 2 diabetic mice by activation of AMP-activated kinase and regulation of PPARγ. Food & Function. 2019 Feb 20;10(2):964-977.

9. Ping Zhao ^#,*, Qian Ming ^#, Junying Qiu, Di Tian, Jia Liu, Jinhua Shen, Qing-Hua Liu and Xinzhou Yang^*. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2+. Molecules. 2018, 23(11), 2934.

10. Ping Zhao^#,*, Qian Ming^#, Mingrui Xiong^#, Guanjun Song, Li Tan, Di Tian, Jia Liu, Zhao Huang, Jingyi Ma, Jinhua Shen, Qing-Hua Liu, Xinzhou Yang^*. Dandelion chloroform extract promotes glucose uptake via the AMPK/GLUT4 pathway in L6 cells. Evidence-Based Complementary and Alternative Medicine. 2018 Nov 7;2018:1709587.

11. Hao Xu^#, Ping Zhao^#, Wen-Jing Zhang^#, Jun-Ying Qiu^#, Li Tan, Xiao-Cao Liu, Qian Wang, Xi Luo, Yu-Shan She, Dun-An Zang, Bei-Bei Liu, Lei Cao, Xiao-Xue Zhao, Yuan-Yuan Chen, Meng-Yue Li, Jinhua Shen, Yong-Bo Peng, Lu Xue, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Gangjian Qin, Qing-Hua Liu^* . Generation and role of oscillatory contractions in mouse airway smooth muscle. Cell Physiol Biochem. 2018 Jun 25;47(4):1546-1555.

12. Mingrui Xiong^#, Yun Huang^#,Yajing Liu, Mi Huang, Guanjun Song, Qian Ming, Xinhua Ma, Jie Yang, Shihao Deng, Yanzhang Wen, Jinhua Shen, Qing-Hua Liu, Ping Zhao^*, Xinzhou Yang^*. Antidiabetic activity of Ergosterol from Pleurotus ostreatus in KK-Ay Mice with Spontaneous Type 2 Diabetes Mellitus. Molecular Nutrition and Food Research. 2018 Feb;62(3).

13. Yunfang Li^#, Ping Zhao^#, Yu Chen, Yanze Fu, Kuan Shi, Liu Liu, Hui Liu, Mingrui Xiong, Qing-Hua Liu, Guangzhong Yang^* , Yuxiu Xiao^*. Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes. Bioorganic & Medicinal Chemistry. 25 (2017) 6605-6613

14. Jialin Wang^#, Mi Huang^#, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Xinzhou Yang^*, Ping Zhao^*. Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter. FOOD & NUTRITION RESEARCH, 2017 VOL. 61,

15. Wu YF^#，Zhao P^#, Luo X^#, Xu JC, Xue L, Zhou Q, Xiong M, Shen J, Peng YB, Yu MF, Chen W, Ma L，Liu Q-H^*. Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes. Cell & Bioscience. 201705.

16. Yang X#, Deng S#, Huang M, Wang J, Chen L, Xiong M, Yang J, Zheng S, Ma X, Zhao P*, Feng Y*, Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities, Bioorganic & Medicinal Chemistry Letters (2017), 2017 Mar 15;27(6):1463-1466

17. Yang X^#, Huang M, ^# Cai J, Lv D, Lv J, Zheng S, Ma X, Zhao P^*, Wang Q^*. Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR. Nat Prod Res. 2017; 31(10):1150-1155.

18. Qi Zhou^#, Xinzhou Yang^#, Mingrui Xiong, Xiaolan Xu, Li Zhen, Weiwei Chen, Yan Wang, Jinhua Shen, Ping Zhao^*, Qing-Hua Liu^*. Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells. Cellular Physiology and Biochemistry. 2016 May 9. 38: 2030-2040.

19.Yang X^#, Yang J^#, Xu C, Huang M, Zhou Q, Lv J, Ma X, Ke C, Ye Y, Shu G^*, Zhao P^*. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice. Journal of Ethnopharmacology. 2015 June 5. 171: 161-170.  

20. Jing Yang^#, Xinzhou Yang^*, Chao Wang, Qinxiong Lin, Zhinan Mei, Ping Zhao^*. Sodium-glucose-linked transporter 2 inhibitors from Sophora flavescens. Medicinal Chemistry Research. 2015 March. 24: 1265-1271.

21. Jing Yang^#, Ping Zhao^#, Qi Zhou, Chao Wang, Dingrong Wan, Guangwen Shu, Zhinan Mei, Xinzhou Yang^*. Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. Via Activation of AMP-activated Protein Kinase in Type 2 Diabetic Mice. Evidence-based Complementary and Alternative Medicine. 2014 September 2.

22. Ping Zhao^#, Lu Yang^#, Jamie A. Lopez, Junmei Fan, James G. Burchfield, Li Bai, Wanjin Hong, Tao Xu^* and David E. James^*. Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. J Cell Sci. 2009 October 122: 3472-3480.

23. Ping ZHAO^#, Wei LI^#, Yong-Ming DONG^#, Dan ZHU, An-Lian QU, Tao XU, and Zheng-Xing WU^*. Kir6.2ΔC26 channel traffics to plasma membrane by constitutive exocytosis. Acta Biochim Biophys Sin. 2006 Feb; 38(2):136-41.

24. Hu ZT^#, Zhao P^#, Liu J^#, Wu ZX^*, Xu T^*. Alpha-latrotoxin triggers extracellular Ca2+-dependent exocytosis and sensitizes fusion machinery in endocrine cells. Acta Biochim Biophys Sin. 2006 Jan; 38(1):8-14.

（四）授權(quán)專利

1. 一種蒲公英氯仿提取物及其制備方法和用途。申請(qǐng)人：趙平，熊明睿，劉慶華，談麗。專利號(hào)：ZL 201710286429.5授權(quán)日：2020.05.15

2. GLUT4基因敲除的sgRNA、A459細(xì)胞系及其構(gòu)建方法。申請(qǐng)人：趙平，劉佳，張穎。專利號(hào)：ZL201910614661.6 授權(quán)日：2021.06.15

3. 紅花有機(jī)溶劑部提取物在制備氣道平滑肌舒張藥物中的應(yīng)用。申請(qǐng)人：劉慶華，趙平，談麗。專利號(hào)：ZL201410810748.8授權(quán)日：2014.12.23

4. 一種治療糖尿病的藥物組合物及其制備方法和用途。申請(qǐng)人：楊新洲，黃蘊(yùn)?趙平，鄭思建，黃密。專利號(hào)：ZL201710577168.2授權(quán)日：2018.10.26

5. 一種白刺花黃酮提取物及其制備方法和用途。申請(qǐng)人：楊新洲，黃蘊(yùn)，宋萍，趙平，田迪，郝吉，呂奕兵。專利號(hào)：ZL201810717809.4授權(quán)日：2021.08.13

6. 竹黃乙酸乙酯萃取物用于制備防治糖尿病藥物的用途。申請(qǐng)人：楊新洲，周琦，楊靜，趙平，黃密。專利號(hào)：ZL201510473612.7授權(quán)日：2018.09.28

四、教學(xué)活動(dòng)及成果

（一）承擔(dān)課程

本科生課程：分子生物學(xué)；基因工程實(shí)驗(yàn)；生物化學(xué)實(shí)驗(yàn)。

研究生課程：科技論文寫作；生物儀器分析。

（二）教學(xué)成果

主持教育部供需對(duì)接就業(yè)育人項(xiàng)目一項(xiàng)。主持校級(jí)教研教改項(xiàng)目6項(xiàng)。發(fā)表教改論文9篇。指導(dǎo)省級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練項(xiàng)目5項(xiàng)。指導(dǎo)全國(guó)大學(xué)生生命科學(xué)競(jìng)賽省級(jí)二等獎(jiǎng)一項(xiàng)。