出生年月：1974年9月

民族：漢族

職稱：教授，藥學碩士生導師

學科專業：藥理學和生藥學

研究方向：尹世金，教授，副院長，碩士生導師。2009年獲武漢大學微生物學專業博士學位，先后在美國University of Texas Health Science Center at Houston和Washington University in St Louis從事藥理學和神經生物學博士后研究工作。主要從事離子通道藥理學研究，以疾病相關性離子通道蛋白為靶點，研究生物活性多肽和有機小分子在感覺過敏性反應（痛和癢）及自身免疫性疾病發生中的作用。發現瞬時電位受體通道TRPV1和TRPA1介導類維生素A的痛覺過敏反應；證明人源性Beta防御素2通過直接作用于免疫細胞tlr4受體，誘導細胞因子釋放并作用于小鼠背根神經節細胞TRPV1通道而致癢；闡明了Kv1.3通道介導蝎、蜈蚣毒素多肽和傣藥龍血竭中查爾酮類化合物的免疫抑制作用。主持國家自然科學基金3項，主持和參與科技部國家重點研發計劃等省部級項目10余項；發表研究論文80余篇，其中包括Immunity、Nat Commun和The Journal of Clinical Investigation等自然指數收錄的SCI論文40余篇；獲國家發明專利4項；獲湖北省科學技術進步一等獎、二等獎各一項；獲湖北省教學成果二等獎一項；獲民族醫藥協會科技進步一等獎一項?，F任中國民族醫藥協會理事和智庫專家、湖北省中醫藥學會常務理事、湖北省藥學會中藥和天然藥專業委員會委員、湖北省毒理學會理事。獨立承擔了《生物化學》、《生物化學實驗》、《解剖生理學實驗》等多門課程的教學工作。

電子郵箱：yinshijinyf@163.com

一、主持和參與的主要省部級研究項目：

1、湖北省自然科學基金創新發展聯合基金重點項目，2024AFD262，參芪升免方對膀胱癌生長抑制作用及醫院制劑研究，2024/5-2027/5、20萬元、在研、主持。

2、國家重點研發計劃中醫藥現代化研究重點專項項目下設一級子項目，2019YFC1712402，經典藏藥如意珍寶片和白脈軟膏的藥效分析與現代藥理研究，2019/7-2023/7、107萬元、結題、子課題負責人

3、企事業單位委托項目，HZY19025，一種龍血素B衍生物的全合成及其治療類風濕性關節炎藥效評價，2019/08-2022/7、20萬元、在研、主持。

4、武漢市國際科技合作計劃項目，2017030209020256、Kv1.3通道介導查爾酮類化合物治療自身免疫疾病的機制、2017/06-2019/12、20萬元、結題、主持。

5、湖北省技術創新專項(對外科技合作類)，2017AHB067、傳統中藥止癢分子機制的國際合作研究、2017/06-2019/12、30萬元、在研、參與。

6、國家自然科學基金應急管理項目，81641186、龍血竭中的Kv1.3阻斷劑及其自身免疫調節作用、2017/01-2017/12、10萬元、已結題、主持。

7、湖北省技術創新專項重大項目，2016ACA138，基于天然產物來源的生物活性化合物庫設計生產及應用開發關鍵技術研究，2016/09-2018/12、100萬元、已結題、參與。

8、國家自然科學基金面上項目，81373379、中國蜈蚣目物種多樣性調查及藥用物種轉錄組學研究、2014/01-2017/12、70萬元、已結題、主持。

9、湖北省自然科學基金面上項目，2015CFB491、龍血竭治療自身免疫疾病的機制研究、2015.4～2017.4、3萬元、已結題、主持。

10、廣東省科技廳產學研結合項目，010B090400047、嵌入式無線網絡在ICU臨床信息系統的應用、2010/10-2013/06、30萬元、已結題、主持。

11、國家自然科學青年基金項目，30900239、BmαTX14多肽與通道β亞基協同調節鈉通道功能的機制研究、2010/01-2012/12、20萬元、已結題、主持。

二、發表的代表性研究論文：

[1]Zhou YS, Tao HB, Lv SS, Liang KQ, Shi WY, Liu KY, Li YY, Chen LY, Zhou L, Yin SJ*, Zhao QR. Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice. Acta Pharmacol Sin. 2024 Oct;45(10):2045-2060.（SCI1區top，IF8.2，*通訊作者）

[2]Zou Y, Zhao Q, Zhang X, Yu H, Zhou Y, Li Z, Xiao M, Xiang Q, Zhang L, Shi W, Tao H, Chen L, Han B, Yin S*. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats. Front Immunol. 2023 Apr 24;14:1094649. doi: 10.3389/fimmu.2023.1094649. PMID: 37168850; PMCID: PMC10165104.（SCI2區，IF5.7，*通訊作者）

[3]Zhao Q, Zhang X, Long S, Wang S, Yu H, Zhou Y, Li Y, Xue L, Hu Y, Yin S*. Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel. Mol Pharmacol. 2023 Oct;104(4):133-143. doi: 10.1124/molpharm.122.000658. Epub 2023 Jul 7. PMID: 37419692.（SCI2區，IF4.05，*通訊作者）

[4] Qiang Li , Peng Liu, Chen Wu , Lijie Bai , Zhongyun Zhang, Zilu Bao , Min Zou, Zhaoxiang Ren, Lin Yuan, Maochuan Liao, Zhou Lan, Shijin Yin*, Lvyi Chen* . Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia. J Ethnopharmacol. 2022, 298:115679. （SCI2區top，IF5.195，*通訊作者）

[5] Zhang X, Zhao Q, Yang F, Lan Z, Li Y, Xiao M, Yu H, Li Z, Zhou Y, Wu Y, Cao Z, Yin S*. Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58. Mol Pharmacol. 2022,102(3):150-160. （SCI2區，IF4.05，*通訊作者）

[6] Shujuan Shi, Qianru Zhao , Caihua Ke, Siru Long , Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin*. Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels. Frontiers in Pharmacology, 2021, 12:685092.（SCI2區top，IF5.81，*通訊作者）

[7]Yubiao Zhang, Feng Zhang, Shujuan Shi, Xinqiao Liu, Weisong Cai, Guangtao Han, Caihua Ke, Siru Long, Zhiyong Di, Shijin Yin*, Haohuan Li*. Immunosuppressive Effects of a Novel Potassium Channel Toxin Ktx-Sp2 from Scorpiops Pocoki. Cell Biosci. 2019, 9:99。（SCI3區，IF5.03，*通訊作者）

[8]Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Shijin Yin, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS, Hu H. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells.Immunity, 2018，49(1):107-119. (SCI1區，IF 19.734,).

[9]Luo J, Bavencoffe A, Yang P, Feng J, Shijin Yin, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, Hu H. Zinc inhibits TRPV1 to alleviate chemotherapy-induced neuropathic pain. J Neurosci. 2018, 38(2):474-483. (SCI1區，IF 5.988)

[10] Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Shijin Yin, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol. 2018, 141(2):608-619. (SCI1區，IF 13.06).

[11] Jing Feng, Jialie Luo, Madison R. Mack, Pu Yang, Feng Zhang, Guan Wang, Xuan Gong, Tao Cai, Zhinan Mei, Brian Kim, Shijin Yin*, Hongzhen Hu. The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice. Journal of Allergy and Clinical Immunology, 2017, 140(3):885-888. (SCI1區，IF 13.06, *通訊作者).

[12] Zou Y, Zhang F, Li Y, Wang Y, Li Y, Long Z, Shi S, Shuai L, Liu J, Di Z, Shijin Yin*. Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki. Cell & Bioscience. 2017, 7:60.（SCI3區, IF 5.03, *通訊作者).

[13]Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Shijin Yin, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017, 8(1):980. (SCI1區，IF 12.124).

[14] Kim S, Barry DM, Liu XY, Shijin Yin,et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Sci Signal, 2016, 9(437):ra71.(SCI1區, IF 7.359)

[15] Shijin Yin，Yanning Qiu，Zhaohui Pan，Shaobin Li，Zhiyong Di . Chaerilus pseudoconchiformus sp. nov., a new species found in Xizang, and an updated key of the chaerilid scorpions from China (Scorpiones:Chaerilidae)，ZooKeys，2015，495：41-51.（SCI）

[16] Shijin Yin，Yunfeng Zhang，Zhaohui Pan，Shaobin Li，Zhiyong Di ，Scorpiops ingens sp.nov.,found in Xizang, and an updated key of Scorpions from China(Scorpiones:Euscorpidae, Scorpiopinae)，ZooKeys，2015，495：53-61。（SCI）

[17] Kimball C, Luo J, Shijin Yin, Hu H, Dhaka A.The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Mol Pharmacol, 2015, 88(1):131-8.（SCI, IF 3.931）

[18] Shijin Yin，Qinglan Hu，Jialie Luo，Yuxin Li，Chunlan Lu，XuanChen，Hongzhen Hu. Loureirin B, an essential component of Sanguis Draxonis,inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells，Cell & Bioscience，2014，4：78。（SCI3區, IF 5.03,通訊作者）

[19] Shijin,Yin, Jialie Luo, Aihua Qian, Weihua Yu, Hongzhen Hu. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol. 2014,171(6):1510-20 (SCI 2區，IF 5.06, 通訊作者)

[20] Shijin,Yin, Jialie Luo, Aihua Qian, Junhui Du, Qing Yang, Shentai Zhou, Weihua Yu, Guangwei Du, Richard B. Clark, Edgar T. Walters, Susan M. Carlton, and Hongzhen Hu. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. The Journal of Clinical Investigation, 2013, 8:1-11 (SCI1區, IF 12.86)

[21] Feng J, Hu Y, Yi H, Shijin Yin, Han S, Hu J, Chen Z, Yang W, Cao Z, De Waard M, Sabatier JM, Li W, Wu Y. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013, 288(18):12544-53. (SCI 2區, IF 5.7)

[22] Dai, Hui¹、Shijin Yin¹、Li, Tian、Cao, Zhijian、Ji, Yonghua、Wu, Yingliang、Li, Wenxin. Recombinant expression, purification, and characterization of scorpion toxin Bm alpha TX14. Protein Expression and Purification, 2012,82(2): 325-331.(SCI, 共同第一作者)

[23] Na Gao, Jialie Luo, Karen Uray, Aihua Qian, Shijin Yin, Guodu Wang, Xiyu Wang, Yun Xia,Jackie D. Wood, Hongzhen Hu. CaMKII Is Essential for the Function of the Enteric Nervous System. PLoS One.2012;7(8):1-10.（SCI, IF 4.351 ）

[24] Chen Z,Hu Y,Han S,Shijin Yin,He Y,Wu Y,Cao Z,Li W. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol.2011 ;25(4):244-51.(SCI)

[25] Song Han¹, Shijin Yin¹, Hong Yi. Ste′phanie Mouhat, Su Qiu, Zhijian Cao, Jean-Marc Sabatier, Yingliang Wu, and Wenxin Li. Protein-Protein Recognition Control by ModulatingElectrostaticInteractions. J Proteome Res, 2010, 9(6):3118-25（SCI 2區, IF 5.684, 共同第一作者）

[26] Di Z., Cao Z, Wu Y.,Shijin Yin., Gregory D and Li W. Discovery of the centipede family Plutoniumidae(Chilopoda) in Asia: a new species of Theatops from China, and the taxonomic value of spiracle distributions in Scolopendromorpha. Zootaxa, 2010, 2667:51-63.（SCI）

[27] Liu, J., Ma, Y., Shijin Yin., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W.,. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus. Peptides, 2009, 30(4):675-80. (SCI)

[28] Shijin Yin., Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. J Proteome Res,2008, 7, 4890-4897.(SCI 2區, IF 5.67)

[29] Shijin Yin; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L., Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides, 2008，29（9）: 1514-20. (SCI)

[30] Han, S¹.; Yi, H¹.; Shijin Yin¹.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem , 2008, 283, 19058-19065.(SCI 2區, IF 5.7, 共同第一作者)

[31] Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Shijin Yin.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W., A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci, 2008, 33, 43-46.(SCI)

[32] Wu, W¹.; Shijin Yin¹.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W., Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides, 2007, 28, 2306-2312.（SCI, 共同第一作者）

[33] Yi, H.; Cao, Z.; Shijin Yin.; Dai, C.; Wu, Y.; Li, W., Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6, 611-620. (SCI, IF 5.67)

[34] Mao, X.; Cao, Z.; Shijin Yin.; Ma, Y.; Wu, Y.; Li, W., Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun, 2007, 360, 728-734.(SCI)

[35] Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.; Shijin Yin.; Yingliang, W.; Wenxin, L., Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides, 2006, 27, 1235-1240. (SCI）

[36] Zhijian, C.; Chao, D.; Shijin Yin.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L., Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol, 2006, 20, 1-6.(SCI)

[37] Wang, K.;Shijin Yin; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett, 2006, 28, 1767-1772.(SCI)

[38] Liu, X.; Shijin Yin.; Chen, S.; Ma, Q., Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons.Conf Proc IEEE Eng Med Biol Soc, 2005, 5, 4962-4965.(EI)

[39] Xiangming, L.; Su, C.; Shijin Yin.; Zhinan, M., Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. Sci China C Life Sci, 2004, 47, 340-348.(SCI)

三、發明專利

(1) 龍血竭作為制備防治自身免疫性疾病藥物中的應用。2018.6.26，中國發明專利，授權專利號：ZL 2014 1 0565812.0，第一發明人。

(2) 一種龍血素B的衍生物及其制備和應用。2018.7.24,中國發明專利，授權專利號：ZL 2017 1 0519342.8，第一發明人。

(3)一種龍血竭總黃酮的制備方法及應用。2021.09.24，中國發明專利，授權專利號：ZL 2019 1 0150187.6，第一發明人。

(4) 多接入點ZigBee網絡協調器。2012，中國實用新型專利，授權專利號：CN 201220123251.5，第二發明人。

(5) 基于無線通信的人體動作檢測器。2012，中國實用新型專利，授權專利號：CN 201120446464.7，第二發明人。

(6) 基于ZigBee的無線脈搏檢測器。2012，中國實用新型專利，授權專利號：CN 201120446500.X，第二發明人。

(7) 基因工程免疫抑制多肽及制備方法和用途。2009，中國發明專利，授權專利號：CN 101423550B，第五發明人。