出生年月：1965年9月
民族：漢
職稱：教授(二級)、博士生導師
學科專業(yè)：藥理學/藥物化學
研究方向：天然產(chǎn)物心血管藥理學與新藥研發(fā)
電子郵箱：zhaojinhua@mail.kib.ac.cn
工作經(jīng)歷
2015.8，中南民族大學藥學院藥理學研究所，教授(二級)、博士生導師；
2010.4~2018.10，中國科學院昆明植物研究所，研究員(二級)、博士生導師；
1999.6~2010.4，深圳海王集團技術(shù)中心，資深研究員；
1984.6~1993.8，安徽省無為縣太平初級中學，教師。
學習經(jīng)歷
1996.6~1999.6，中山大學生命科學學院，動物學(天然產(chǎn)物藥學方向)博士；
1993.9~1996.6，中山大學生命科學學院，生理學(心血管藥理學方向)碩士；
1988.9~1990.6，安徽教育學院生物系，進修；
1981.9~1984.6，安徽省無為師范學校，中師。
學術(shù)與應用研究：
從事天然產(chǎn)物心血管藥理學活性與機制研究。重點方向是具有心血管藥理活性并具有重復結(jié)構(gòu)單元的天然產(chǎn)物多糖的化學結(jié)構(gòu)、結(jié)構(gòu)修飾、藥效活性、藥理機制及構(gòu)效關系研究。
巖藻糖化糖胺聚糖(fucosylated glycosaminoglycan, FG)結(jié)構(gòu)研究方面，基于“bottom up”策略，通過建立糖苷鍵選擇性解聚技術(shù)及寡糖純化與波譜學結(jié)構(gòu)解析技術(shù)，闡明了一系列不同物種來源的天然FG的確切結(jié)構(gòu)；獲得一系列用于藥理學活性與機制研究的、具有特殊端基結(jié)構(gòu)的純品FG寡糖及其結(jié)構(gòu)修飾產(chǎn)物。
系統(tǒng)研究了FG及其解聚產(chǎn)物、純品寡糖的抗凝抗血栓活性及其藥理學機制特點，重點研究了FG寡糖選擇性抑制內(nèi)源性因子X酶(Tenase, Xase)構(gòu)效關系、必須結(jié)構(gòu)、酶學動力學特點與機制、靶蛋白相互作用的動力學過程與機制。
基于天然FG結(jié)構(gòu)修飾，研制選擇性抑制內(nèi)源性Xase的新靶點抗凝抗血栓新藥LFG-53(First In Class，獲FDA和NMPA臨床許可)，系列專利獲得國內(nèi)、美、日等國授權(quán)，已實現(xiàn)知識產(chǎn)權(quán)及關鍵技術(shù)的企業(yè)技術(shù)轉(zhuǎn)移。
海王集團國家級企業(yè)技術(shù)中心工作期間，組建藥物研發(fā)實驗研究平臺，主管創(chuàng)新藥物研發(fā)。其代表性工作包括：立項并研發(fā)中藥天然藥物1類新藥虎杖苷注射液(臨床批件(現(xiàn)已取得FDA臨床許可))、5類中藥新藥艾心酮片(臨床批件)、中藥大品種改進藥物鼻淵軟膠囊(上市許可)等。
在PNAS、JBC、Carbohydr Polym、Thromb Haemost、Pharmacol Res、Eur J Med Chem、Thromb Res、Int J Biol Macromol、Mar Drugs、BBA、Angew Chem、Chem Eur J等國內(nèi)外學術(shù)期刊上發(fā)表論文百余篇；申請國內(nèi)及PCT發(fā)明專利70余件，已獲中、美、日、澳、等國授權(quán)的發(fā)明專利60余件。
先后主持國家、科學院及省級課題二十余項，包括國家新藥重大專項項目、863課題及引導項目、發(fā)改委重大專項、自然科學基金項目、科技部技術(shù)創(chuàng)新基金項目、科學院創(chuàng)新藥物項目、科學院天然產(chǎn)物應用轉(zhuǎn)化項目、粵港關鍵領域重點突破項目、深港創(chuàng)新圈項目、廣東省教育部產(chǎn)學研結(jié)合項目、云南省應用基礎研究計劃重點項目、云南省重點新產(chǎn)品項目等。
主持承擔的部分課題項目：
國家新藥重大專項：LFG-53新藥臨床前研究(2017~2020)
國家發(fā)改委企業(yè)技術(shù)中心重大項目：① 天然藥物創(chuàng)新能力建設(2008~2012)；
② 創(chuàng)新海洋藥物研究開發(fā)中心建設(2004~2008)
863課題：① 牡蠣生物活性成分的提取及應用研究(1999 ~2001)；
② 中藥1類新藥虎杖苷注射液(2005~2008)
自然基金面上項目：① P-選擇素抑制劑發(fā)現(xiàn)及其抗血栓活性研究(2021~2025)
② FG寡糖抑制Xase藥理機制(2017~2021)；
② FGAG純化結(jié)構(gòu)序列及其對血栓形成與止血功能的影響(2013~2017)
科技部科技型中小企業(yè)技術(shù)創(chuàng)新基金：降血脂藥蔗烷醇膠囊研制(2008~2010)；
科學院技術(shù)百人項目：天然產(chǎn)物成藥性研究技術(shù)平臺建設(2011~2013)；
科學院創(chuàng)新藥物研究院新藥項目：新靶點抗血栓藥物LFG研究(2015~2018)；
科學院天然產(chǎn)物應用轉(zhuǎn)化項目：P-選擇素抑制劑發(fā)現(xiàn)與轉(zhuǎn)化(2016~2018)
科學院自主部署項目：① 活性天然多糖藥代、安全性與應用轉(zhuǎn)化(2015~2019)；
② 基于天然產(chǎn)物及其片段的創(chuàng)新藥物研發(fā)能力建設(2010 ~ 2013)
云南省高端人才項目：基于天然產(chǎn)物及其結(jié)構(gòu)片段的創(chuàng)新藥物研發(fā)(2010~ 2016)
云南省基礎研究計劃重點項目：① LFG組分及其抗凝抗血栓活性(2016~2019)；
② 抑制因子X酶的FG衍生物的構(gòu)效關系及應用價值評價(2013~2016)
廣東省教育部產(chǎn)學研結(jié)合項目：虎杖苷注射液治療腦卒中適應癥研究(2009~2011)
云南省科技計劃項目：抗艾新藥注射用DT-8臨床前預研究(2012~2015)
云南省創(chuàng)新團隊項目：活性天然產(chǎn)物發(fā)現(xiàn)與生物合成(2017~2020年)
粵港關鍵領域重點突破項目：中藥1類新藥虎杖苷注射液(2006 ~ 2009年)
深港創(chuàng)新圈計劃項目：中藥一類創(chuàng)新藥物虎杖苷注射液(2006 ~ 2009年)
獲獎與榮譽
2008年，入選“改革開放三十年廣東省醫(yī)藥行業(yè)杰出科技人才”
2010年，入選“云南省引進高端人才計劃”；
2011年，入選中國科學院百人計劃(技術(shù)百人)
2015年，F.Xase抑制劑學術(shù)研究入選昆明植物研究所年度“十大進展”；
2016年，LFG新藥技術(shù)轉(zhuǎn)移入選昆明植物研究所年度“十大進展(第一位)”；
2017年，入選云南省政府“享受政府特殊津貼人員”
2024年，獲2023年度云南省科學技術(shù)獎(技術(shù)發(fā)明獎)一等獎（第一完成人）
近年發(fā)表的部分學術(shù)論文：
Cui LG, Sun HF, Shang XL, Wen J, Li PF, Yang ST, Chen LX, Huang XY, Li HY, Yin RH*, and Zhao JH. Purification and structural analyses of sulfated polysaccharides from low-value sea cucumber Stichopus naso and anticoagulant activities of its oligosaccharides. Marine Drugs. 2024; 22: 265.
Ma Y, Zuo ZC, Zheng WQ, Yin RH, Wu XW, Ma YJ, Ji MC, Ma WW, Li X*, Xiao WL**, Gao N***, Zhao JH. Structural characterization of a distinct fucan sulfate from Pattalus mollis through an oligosaccharide mapping approach. Carbohyd Res., 2024, 536:109052.
Chen R, Wang WL, Yin RH, Pan Y, Xu C, Gao N*, Luo XD*, and Zhao JH. Structural characterization and anticoagulant activities of a keratan sulfate-like polysaccharide from the sea cucumber Holothuria fuscopunctata. Mar Drugs. 2023, 21: 632.
Lan D, Zhang JL, Shang XL, Yu LJ, Xu C, Wang P, Cui LG, Cheng NQ, Sun HF, Ran JN, Sha L, Yin RH, Gao N*, Zhao JH*. Branch distribution pattern and anticoagulant activity of a fucosylated chondroitin sulfate from Phyllophorella kohkutiensis. Carbohyd Polym. 2023, 321:121304.
Ruzemaimaiti D#, Sun HF#, Zhang JL, Xu C, Chen LX, Yin RH*, Zhao JH*. Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligand. Carbohyd Polym. 2023, 317:121080.
Sun HF, Yang SS, Li PF, Shang XL, Wang P, Zhang JL, Yuan L, Yin RH, Gao N*, Zhao JH*. Comparative assessment of APTT reagents for evaluating anticoagulant sensitivity of fucosylated glycosaminoglycans (FGs) derived from sea cucumbers. Mar Drugs. 2023, 21: 568.
Zuo ZC, He ZC, Ma Y, Xu C, Tao XL, Ning ZM, Gao L, Rehemiding A, Gao N*, Zhao JH*. Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota. Int J Biol Macromol. 2023, 236: 123935.
Li SJ, Wang WL, Lin LS, Yang L, Cai Y, Yang XZ, Zhang TC, Xiao C, Yan H, Gao N*, Zhao JH*. Oligosaccharide blocks PAR1 (Proteinase Activated Receptor 1)-PAR4–mediated platelet activation by binding to thrombin exosite II and impairs thrombosis. Arterioscler, Thromb, Vasc Biol. 2023, 43:253-266.
Xia F#, Lin LS#, Ye YS#, Yang L, Zhao JH*, Xu G*. 11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii. Bioorg Chem. 2023, 140:106834.
Dai MY, Peng W, Lin LS, Wu, ZXE, Zhang T, Zhao Q, Cheng Y, Lin QX, Zhang BB, Liu AM, Rao QR, Huang JF, Zhao JH*, Gonzalez FJ*, Li F*. Celastrol as an intestinal FXR inhibitor trigger tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine. 2023, 121: 155054.
Wang WL#, Mao H#, Li SJ, Zhang LL, Yang L, Yin RH*, Zhao JH*. Branched chondroitin sulfate oligosaccharides derived from the sea cucumber Acaudina molpadioides stimulate neurite outgrowth. Mar Drugs. 2022, 20: 653.
Tao XL, Wang WL, Shi X, Lan D, Mao H, Ning ZM, Gao L, Zuo ZC, Xu C, Yang ZQ, Wang Y, Zuo ZL, Gao N*, Zhao JH*. Peroxidative depolymerization of fucosylated glycosaminoglycan: Bond-cleavage pattern and activities of oligosaccharides. Carbohyd Polym. 2022, 295:119855.
Yin RH, Pan Y, Cai Y, Yang F, Gao N, Ruzemaimaiti D, Zhao JH*. Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea. Carbohyd Polym. 2022, 294: 119826.
Li XM, Sun HF, Ning ZM, Yang WJ, Cai Y, Yin RH*, Zhao JH*. Mild acid hydrolysis on Fucan sulfate from Stichopus herrmanni: Structures, depolymerization mechanism and anticoagulant activity. Food Chem. 2022, 395: 133559.
Liu XX, Ning ZM, Zuo ZC, Wang P, Yin RH, Gao N*, Wu B, Zhao JH. The glycosidic bond cleavage and desulfation investigation of fucosylated glycosaminoglycan during mild acid hydrolysis through structural analysis of the resulting oligosaccharides. Carbohyd Res. 2022, 511: 108493.
Gao L, Xu C, Tao XL, Zuo ZC, Ning ZM, Wang LH, Gao N*, Zhao JH*. Structure elucidation of fucan sulfate from sea cucumber Holothuria fuscopunctata through a bottom-up strategy and the antioxidant activity analysis. Int J Mol Sci. 2022, 23: 4488.
Ning ZM, Wang P, Zuo ZC, Tao XL, Gao L, Xu C, Wang ZY, Wu B*, Gao N*, Zhao JH. A fucan sulfate with pentasaccharide repeating units from the sea cucumber Holothuria floridana and its anticoagulant activity. Mar Drugs. 2022, 20: 377.
Li XM, Li SN, Liu J, Lin LS, Sun HF, Yang WJ, Cai Y, Gao N, Zhou LT, Qin HB*, Yin RH*, Zhao JH*. A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity. Carbohyd Polym. 2021, 256: 117513.
Li SN, Zhong W, Pan Y, Lin LS, Cai Y, Mao H, Zhang TC, Li SJ, Chen R, Zhou LT, Wang WL, Cui QH*, Yin RH*, Huang SX*, Zhao JH*. Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis. Carbohyd Polym. 2021, 269: 118290.
Zhou LT, Yin RH, Gao N, Sun HF, Chen DY, Cai Y, Ren L, Yang L, Zuo ZL*, Zhang HB*, Zhao JH*. Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis. Pharmacol Res. 2021, 166: 105527.
Chen R, Yin RH, Li SN, Pan Y, Mao H, Cai Y, Lin LS, Wang WL, Zhang TC, Zhou LT, Gao N*, Luo XD*, Zhao JH*. Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization. Carbohyd Polym. 2021, 270: 118368.
Yin RH, Zhou LT, Gao N, Lin LS, Sun HF, Chen DY, Cai Y, Zuo ZL, Hu KF, Huang SX*, Liu JK*, Zhao JH*. Unveiling the disaccharide-branched glycosaminoglycan and anticoagulant potential of its derivatives. Biomacromolecules. 2021, 22(3): 1244-55.
Ma Y, Gao N, Zuo ZC, Li SN, Zheng WQ, Shi X, Liu QP, Ma T, Yin RH*, Li X*, Zhao JH*. Five distinct fucan sulfates from sea cucumber Pattalus mollis: Purification, structural characterization and anticoagulant activities. Int J Biol Macromol. 2021, 186: 535.
Shi X#, Guan RW#, Zhou LT, Zuo ZC, Tao XL, Wang P, Zhou YR, Yin RH, Zhao LY*, Gao N*, Zhao JH. Structural characterization and heparanase inhibitory activity of fucosylated glycosaminoglycan from Holothuria floridana. Mar Drugs. 2021, 19(3): 162.
Liu S #, Zhang TC #, Sun HF, Lin LS, Gao N, Wang WL, Li SJ, Zhao JH *. Pharmacokinetics and pharmacodynamics of a depolymerized glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in rats by bioanalytical methods. Mar Drugs. 2021, 19: 212.
Lin LS, Li SJ, Gao N, Wang WL, Zhang TC, Yang L, Yang XZ, Luo D, Ji X*, Zhao JH*. The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants. Mar Drugs. 2021, 19(9): 487-499.
Lin LS, Yang L, Chen J, Zhou LT, Li SJ, Gao N, Zhao JH*. High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion. Platelets. 2021, 32(7): 975.
Mao H#, Cai Y#, Li SN, Sun HF, Lin LS, Pan Y, Yang WJ, He ZC, Chen R, Zhou LT, Wang WL, Yin RH*, Zhao JH*. A new fucosylated glycosaminoglycan containing disaccharide branches from Acaudina molpadioides: Unusual structure and anti-intrinsic tenase activity. Carbohyd Polym. 2020, 245: 116503-12.
Yang WJ#, Chen DY#, He ZC, Zhou LT, Cai Y, Mao H, Gao N*, Zuo ZL*, Yin RH*, Zhao JH. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber. Carbohyd Polym. 2020, 233: 115844-52.
Lin LS, Zhao LY, Gao N, Yin RH, Li SJ, Sun HF, Zhou LT, Zhao GL, Purcelle SW, Zhao JH*. From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors. Blood Reviews. 2020, 39: 100615.
Gao N, Chen R, Mou RR, Xiang JY, Zhou K, Li Z, Zhao JH*. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata. Int J Biol Macromol. 2020, 164: 3421–3428.
Sun HF#, Gao N#, Ren L, Liu S, Lin LS, Zheng WQ, Zhou LT, Yin RH, Zhao JH*. The components and activities analysis of a novel anticoagulant candidate dHG-5. Eur J Med Chem. 2020, 207:112796-801.
Zhou LT#, Gao N#, Sun HF, Xiao C, Yang L, Lin LS, Yin GH, Li Z, Zhang HB*, Ji X*, Zhao JH*. Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk. Thromb Haemost. 2020, 120(4):607-619.
Liu XX, Zhang ZX, Mao H, Wang P, Zuo ZC, Gao L, Shi X, Yin RH, Gao N*, Zhao JH*. Characterization of the hydrolysis kinetics of fucosylated glycosaminoglycan in mild acid and structure of the resulting oligosaccharides. Mar Drugs. 2020, 18: 286-302.
Luo D, Xu JP, Chen XJ, Zhu X, Liu S, Li J, Xu XT, Ma X*, Zhao JH*, Ji X*. EGCG attenuates salt-induced hypertension and renal injury in Dahl salt-sensitive rats. Sci Rep. 2020, 10: 4783-93.
Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK, Liu SB, Yin RH*, Zuo ZL*, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. Carbohyd Polym. 2019, 224:115146.
He ZC, Zhou LT, Lin LS, Yin RH*, Zhao JH*. Structure and heparanase inhibitory activity of a new glycosaminoglycan from the slug Limacus ?avus. Carbohyd Polym, 2019, 220:176–184.
Yang WJ#, Cai Y#, Yin RH, Lin LS, Li ZK*, Wu MY*, Zhao JH*. Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber. Int J Biol Macromol. 2018, 115: 1055-1062.
Xiao C, Zhao LY, Gao N, Wu MY, Zhao JH*. Nonasaccharide inhibits intrinsic factor Xase complex by binding to factor IXa and disrupting factor IXa-Factor VIIIa interactions. Thromb Haemost. 2019, 19: 705–715.
Luo D, Chen X, Zhu X, Liu S, Li J, Xu J, Zhao JH*, Ji X*. Pu-Erh tea relaxes the thoracic aorta of rats by reducing intracellular calcium. Front Pharmacol. 2019, 10:1-13.
Zheng WQ, Zhou LT, Lin LS, Cai Y, Sun HF, Zhao LY, Gao N, Yin RH*, Zhao JH*. Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumber Pattalus mollis. Mar Drugs. 2019, 17(4): 198.
Guan RW, Peng Y, Zhou LT, Zheng WQ, Liu XX, Wang P, Yuan QX, Gao N, Zhao LY*, Zhao JH*. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan from Apostichopus japonicus: Analysis of its depolymerized fragments. Mar Drugs. 2019, 17(4): 195.
Lin LS, Xu L, Xiao C, Zhou LT, Gao N, Wu MY, Zhao JH*. Plasma contact activation by a fucosylated chondroitin sulfate and its structure–activity relationship study. Glycobiology. 2018, 8(10): 754.
He HQ, Chen D, Li XM, Li CJ, Zhao JH *, Qin HB *. Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate. Org Biomol Chem.2019, 17: 2877.
Yin RH, Zhou LT, Gao N, Li Z, Zhao LY, Shang FN, Wu MY*, Zhao JH*. Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition. J Biol Chem. 2018, 293(36): 14089.
Shang FN#, Mou RR#, Zhang ZD#, Gao N, Lin LS, Li ZK, Wu MY*, Zhao JH*. Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors. Carbohyd Polym. 2018, 195: 257-266.
Zhang X, Liu H, Lin L, Yao W, Zhao JH, Wu MY*, Li ZJ*. Synthesis of fucosylated chondroitin sulfate nonasaccharide as a novel anticoagulant targeting intrinsic factor Xase complex. Angew Chem Int Ed. 2018, 57(39): 12880.
Zhao LY, Qin YJ, Guan RW, Zheng WQ, Liu JK,Zhao JH*. Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions. Carbohyd Polym. 2018, 186: 217-225.
Liu J, Zhou LT, He ZC, Gao N, Shang FN, Xu JP, Li Z, Yang ZM, Wu MY*, Zhao JH*. Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica. Carbohyd Polym. 2018, 181: 433-441.
Xu L#, Gao N#, Xiao C, Lin LS, Purcell SW, Wu MY*, Zhao JH*. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition. Eur J Med Chem. 2018, 154:133-143.
Shang FN#, Gao N#, Yin RH, Lin LS, Xiao C, Zhou LT, Li Z, Purcell SW, Wu MY*, Zhao JH*. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors. Eur J Med Chem. 2018, 148: 423.
Zhang X, Yao W, Xu XJ, Sun HF, Zhao JH, Meng XB, Wu MY, Li ZJ*. Synthesis of fucosylated chondroitin sulfate glycoclusters: a robust route to new anticoagulant agents. Chem.-Eur J. 2018, 24(7): 1694-1700.
Qin YJ, Yuan QX, Zhang YX, Li JL, Zhu XJ, Zhao LL, Wen J, Liu JK, Zhao LY,* Zhao JH*. Enzyme-assisted extraction optimization, characterization and antioxidant activity of polysaccharides from sea cucumber Phyllophorus proteus. Molecules. 2018, 23: 590.
Cai Y, Yang WJ, Yin RH, Zhou LT, Li ZK, Wu MY*, Zhao JH*. An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer. Carbohyd Res. 2018, 464: 12.
Li XM, Luo L, Cai Y, Yang WJ, Lin LS, Li Z, Gao N, Purcell SW, Wu MY*, Zhao JH*. Structural elucidation and biological activity of a highly regular fucosylated glycosaminoglycan from the edible sea cucumber Stichopus herrmanni. J Agric Food Chem. 2017, 65(42): 9315-9323.
Xiao C, Lian W, Zhou LT, GaoN, Xu L, Chen J, Wu MY*, Peng WL*, Zhao JH*. Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors, Thromb Res. 2016, 146: 59-68.
Zhao LY#, Wu MY#, Xiao C, Yang L, Zhou LT, Gao N, Li Z, Chen J, Chen JC, Liu JK*, Qin HB*, Zhao JH*. Discovery of an intrinsic tenase inhibitor, pure nonasaccharide from fucosylated glycosamino-glycan. PNAS. 2015, 112: 8284-8289.
Gao N#, Lu F#, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. Carbohyd Polym. 2015, 127(3): 427–437;
Wu MY#, Wen DD#, Gao N, Xiao C, Yang L, Xu L, Lian W, Peng WL, Jiang JM*, Zhao JH*, Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase. Eur J Med Chem. 2015, 92: 257-269
Wu MY, Xu L, Zhao LY, Xiao C, Gao N, Luo L, Yang L, Li Z, Chen LY,* Zhao JH*. Structural analysis and anticoagulant activities of the novel sulfated fucan possessing a regular well-defined repeating unit from sea cucumber. Mar Drugs. 2015, 13: 2063-2084
Lian W, Huang N, Li Z, Zheng YT*, Peng WL*, Zhao JH*. Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope. Biochim Biophys Acta. 2013, 1830: 4681-4691.
Zhao LY#, Lai SS#, Huang R, Wu MY, Gao N, Xu L, Qin HB*, Peng WL*, Zhao JH. Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage. Carbohyd Polym. 2013, 98(2): 1514-1523.
Luo L, Wu MY, Xu L, Lian W, Xiang JY, Lu F, Gao N, Zhao JH*. Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers. Mar Drugs. 2013, 11: 399-417.
Huang N, Wu MY, Zheng CB, Zhu L, Zhao JH*, Zheng YT*. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry. Carbohyd Res. 2013, 380: 64-69.
近年獲得授權(quán)的發(fā)明專利
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. US 9896517b2 [美國授權(quán) 2018-02-20]
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low-molecular-weight-glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. 特許6293862 [日本授權(quán) 2018-02-23]
Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low-molecular-weight-glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivate thereof 特許6248179 [日本授權(quán) 2017-11-24]
Zhao JH, Kang H, Wu MY, Zeng WZ, Li Z, Gao Y, Cui J, Wang ZG, Feng HL, Yu, L. Depolymerized glycosaminoglycan from Thelenota ananas and preparation method thereof. AUS 2010324437 [澳大利亞授權(quán) 2015-04-02]
趙金華, 劉吉開, 吳明一, 高娜, 盧鋒, 李姿. 一種低分子量糖胺聚糖衍生物及其藥物組合物和其制備方法與應用. ZL 201310099800.9 [授權(quán) 2015-09-16]
劉吉開, 鄭永唐, 趙金華, 吳明一, 黃寧, 李姿, 高娜, 文丹丹, 連武, 何江波. 低分子量巖藻糖化糖胺聚糖的羧基還原衍生物及其制備方法與用途. ZL 201110435559.3[授權(quán) 2013-10-02]
趙金華, 吳明一, 高娜, 文丹丹, 連武, 李姿. 一種巖藻糖化糖胺聚糖衍生物及其制備方法. ZL 2011 10318704. [授權(quán)2014- 04-09]
趙金華, 吳明一, 高娜, 李姿, 賴森森, 趙龍巖. 一種含末端 2,5-脫水塔羅糖或其衍生物的低分子量糖胺聚糖衍生物. ZL 201310127447.0 [授權(quán) 2015-11-04]
趙金華, 何金星, 吳明一, 劉峙汶, 高娜, 趙龍巖, 李姿, 盧鋒, 徐麗. Fuc3S4S取代的低聚糖胺聚糖及其制備方法. CN 201410007855.7 [授權(quán) 2016-08-31]
吳濱, 孫文武, 曹沛, 趙金華, 楊蓮. N-喹啉基取代的β-內(nèi)酰胺類化合物及其藥物組合物和合成方法與應用. ZL 201310428596 [授權(quán) 2016-03-02]
趙金華, 吳明一, 李姿. 一種抗消化性潰瘍的組合物及其應用. ZL 201310680958.5 [授權(quán)2016- 04-06]
趙金華, 吳明一, 李姿. 一種含石斛多糖和蒼術(shù)硬脂的組合物及其應用. ZL 20131068 0378.6 [授權(quán) 2016-03-30]
趙金華，何金星，吳明一，趙龍巖，劉峙汶，楊蓮，李姿，高娜，肖創(chuàng)，徐麗，陳鈞，周路坦. 一種抑制內(nèi)源性因子X酶活性的寡糖類化合物及其藥物組合物. ZL 201410549676.6 [授權(quán) 2017-12-01]
