基本信息

性別: 男

政治面貌: 中共黨員

出生日期: 02/16/1992

電子郵箱: hm19920216@126.com

ORCID: 0000-0002-7669-7364

教育及工作經歷  

2024.9 - 至今 ：中南民族大學藥學院，講師

2023.10 - 2024.9：武漢朗來科技發展有限公司， 先后任轉化醫學項目負責人、體外高級研究員

2019.5 - 2019.11：美國哈佛-麻省理工-博德研究所，聯培博士，合作導師：Melina Claussnitzer教授

2018.10 - 2023.6：瑞典隆德大學醫學院，博士，導師：Sebastian Kalamajski研究員，Paul Franks教授，Hindrik Mulder 教授

2018.1 - 2018.10：瑞典隆德大學醫學院，研究助理，導師：Paul Franks教授

2014.9 - 2017.6：中南民族大學藥學院，碩士

2010.9 - 2014.6：中南民族大學藥學院，學士

研究興趣

[1] 功能基因組學 - 基因與環境, 基因與藥物相互作用對肥胖和2型糖尿病的影響的分子機制研究

[2] 肥胖和2型糖尿病的致病基因及其分子機制研究

[3] 天然產物的高通量抗糖尿病活性篩選的細胞模型構建

[4] 民族藥來源的天然藥物抗2型糖尿病和肥胖的活性與作用機制研究

參與項目

[1] Novel Approach to Systematically Characterize Exercise- and Nutrient-responsivegenes in Type 2 diabetes and cardiovascular disease，1545萬人民幣，歐盟研究委員會，2017.2-2024.1 (主要參與人)

[2] Precision medicinsk livstil som metod f?r f?rebyggande av typ 2-diabetes，330萬人民幣，瑞典研究委員會，2020.1-2024.1 (主要參與人)

[3] Investigation of genetic variants in MTIF3, relevant for personalised obesity treatment，14萬人民幣，Crafoordska stiftelsen基金會，2021.8-2023.6 (主要參與人)

[4] Creating a human disease in a dish model of diabetes by genetically engineering iPSCs using CRISPR/Cas9，35萬人民幣，Crafoordska stiftelsen基金會，2019.6-2021.6 (主要參與人)

[5] 基于GLUT4和SGLT2雙靶點的槐屬藥用植物抗糖尿病藥效物質基礎及作用機制研究，66萬人民幣，國家自然科學基金委員會，2016.1-2019.12 (主要參與人)

論文發表

以第一作者發表論文11篇，其中在自然指數期刊發表2篇，中科院1區TOP期刊發表5篇，中科院2區期刊發表3篇，中科院3區期刊發表2篇，中科院4區期刊發表1篇，具體如下：

[1] Mi Huang, Daniel Coral, Hamidreza Ardalani, Peter Spegel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W Franks*, Sebastian Kalamajski*. Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function. Elife, 12: e84168.（中科院1區，Top期刊，Nature指數收錄, IF: 7.7）

[2] Mi Huang, Melina Claussnitzer, Alham Saadat, Daniel E. Coral, Sebastian Kalamajski*, Paul W. Franks*. Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover. Diabetologia, 2023, 66: 1289-1305. （中科院1區，Top期刊，被評為亮點文章， IF: 8.2）

[3] Mi Huang, Rashmi B. Prasad, Daniel E. Coral, Line Hjort, Daniel T. R. Minja, Hindrik Mulder, Paul W. Franks*, Sebastian Kalamajski*. Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function. Diabetes, 2024: db230531.（ 中科院1區，Top期刊，被評為亮點文章， IF: 7.7）

[4] Zhou, Qianying^#, Mi Huang^#, Yongcun Shen, Zhenling Chen, Liying Xu, and Zhigang Yang.Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4+1] Annulation of Difluorocarbene and Antitumor Activity Evaluation. Organic Letters, 2024, 26, 6, 1212–1217.  (中科院1區，Nature指數收錄，Top期刊，#并列一作，IF: 5.2)

[5] Xinzhou Yang^#, Mi Huang^#, Jie Yang, Jialin Wang, Sijian Zheng, Xinhua Ma, Jinyan Cai, Shihao Deng, Guangwen Shu, Guangzhong Yang*. Activity of isoliensinine in improving the symptoms of type 2 diabetic mice via activation of AMP-activated kinase and regulation of PPARγ. Journal of Agricultural and Food Chemistry, 2017, 65: 7168-7178. (中科院1區，Top期刊，#并列一作，IF: 6.1)

[6] Mi Huang, Ping Zhao, Mingrui Xiong, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang, Tong-Cun Zhang. Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambusicola in KK-Ay mice with spontaneous type 2 diabetes mellitus. Journal of Ethnopharmacology, 2016, 191: 71-81. (中科院2區，Top期刊，IF: 5.24)

[7] Mi Huang^#, Shihao Deng^#, Qianqian Han, Ping Zhao, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang*. Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. in KK-Ay mice. Frontiers in Pharmacology, 2016, 7:288. (中科院2區，Top期刊，#并列一作，IF: 5.60)

[8] Li Chen^#, Sijian Zheng^#, Mi Huang^#, Xinhua Ma, Jie Yang, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*. β-Ecdysterone from Cyanotis arachnoidea exerts hypoglycemic effects through activating IRS-1/Akt/GLUT4 and IRS-1/Akt/GLUT2 signal pathways in KK-Ay mice. Journal of Functional Foods, 2017, 39: 123-132. (中科院2區，Top期刊，#并列一作，IF: 5.60)

[9] Xinzhou Yang^#, Mi Huang^#, Sijian Zheng, Xinhua Ma, Dingrong Wan, Yunjiang Feng*. Liquid chromatography with mass spectrometry and NMR spectroscopy based discovery of cytotoxic principles from Daphne tangutica Maxim. Journal of Separation Science, 2016, 39: 2179-2187. (中科院3區，#并列一作，IF: 3.10)

[10] Jialin Wang^#, Mi Huang^#, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Xinzhou Yang, Ping Zhao*. Anti-diabetic activity of stigmasterol from soybean oil by targeting GLUT4 glucose transporter. Food & Nutrition Research, 2017, 61: 1364117. (中科院4區，#并列一作，IF: 3.30)

[11] Xinzhou Yang^#, Mi Huang^#, Jinyan Cai, Dan Lv, Jingnan Lv, Sijian Zheng, Xinhua Ma, Ping Zhao, Qiang Wang. Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR. Natural Product Research, 2017, 31: 1150-1155. (中科院3區，#并列一作，IF: 2.20)

以共同作者參與發表論文18篇，在中科院1區期刊發表1篇，中科院2區期刊發表4篇，僅列舉Top期刊如下：

[1] Sebastian Kalamajski, Mi Huang, Jonathan Dalla-Riva, Maria Keller, Adem Y Dawed, Ola Hansson, Ewan R Pearson, MetGen Plus Consortium, Hindrik Mulder, Paul W Franks*. Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression. Human Molecular Genetics, 31: 491-498.（中科院2區，Top期刊， IF: 3.5）

[2] Sevda Gheibi, Luis Rodrigo Cataldo, Alexander Hamilton, Mi Huang, Sebastian Kalamajski, Malin Fex, Hindrik Mulder*. Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes. Diabetes, 72: 491-498.（中科院1區，Top期刊，IF: 7.7）

[3] Jie Yang, Hao Chen, Qiang Wang, Shihao Deng, Mi Huang, Xinhua Ma, Ping Song, Jingwen Du, Yun Huang, Yanzhang Wen, Yongshen Ren, Xinzhou Yang*. Inhibitory effect of kurarinone on growth of human non-small cell lung cancer: an experimental study both in vitro and in vivo studies. Frontiers in Pharmacology, 2018, 9: 252.（中科院2區，Top期刊，IF: 5.60）