出生年月：1972.12  民族：漢族

學歷學位：醫(yī)學博士   職稱：教授

學科專業(yè)：病理學、藥理學

電話： 027-67842332

電子郵箱：liys2006@mail.scuec.edu.cn

研究方向包括：包括肝癌在內(nèi)腫瘤形成的病理學機制及抗腫瘤民族藥物的干預研究；皮膚損傷機制及民族藥物干預。

1997年畢業(yè)于湖南中醫(yī)學院（現(xiàn)更名湖南中醫(yī)藥大學）臨床醫(yī)療專業(yè)；1999年3月赴日本國立廣島大學醫(yī)學部留學，于2006年3月，獲人體病理學專業(yè)博士（醫(yī)學）學位；2006年4月至2009年3月日本國立廣島大學大學院醫(yī)學部任博士研究員；2009年4月任中南民族大學副教授；2015年7月任中南民族大學教授。

多年來主要從事包括肝癌在內(nèi)腫瘤發(fā)生、發(fā)展的病理學機制及抗腫瘤民族藥物的研發(fā)工作，特別是重點研究銀屑病、特應(yīng)性皮炎等慢性疑難皮膚疾患的發(fā)病機制和民族藥物的作用機制。

工作期間，主持或參與包括國家自然科學基金在內(nèi)項目等十余項，并在Nanomedicine NBM、Journal of Ethnopharmacology、Journal of Agricultural and Food Chemistry、International Journal of Nanomedicine、Biomedicine & Pharmacotherapy等國際或國內(nèi)學術(shù)刊物上發(fā)表了70余篇研究論文，獲國家發(fā)明專利21項，其中包括美白祛斑、氣血雙補、抑郁康復等10項專利技術(shù)已經(jīng)完成了科技成果轉(zhuǎn)化。

一、獎勵

一等獎，論文題名“浸潤性微小乳頭癌的淋巴行性轉(zhuǎn)移及血管新生因子的表達”；第13屆日本乳腺癌學術(shù)總會，2005；

一等獎，論文題名“The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast”；第8屆日本乳腺癌學會優(yōu)秀論文獎，2007

二、近五年代表性研究論文(#為共同第一作者；*為通訊作者)

1. Zhang Z, Ma SY, Yin X, Li YS*, Tang HB. Topical frankincense treatment for frostbite based on microcirculation improvements. Journal of Ethnopharmacology. 2025, 336:118728. doi: 10.1016/j.jep.2024.118728.

2. Yin X, Gu HW, Ning D, Li YS, Tang HB. Testosterone Exacerbates the Formation of Liver Cancer Induced by Environmental N-Nitrosamines Exposure: Potential Mechanisms and Implications for Human Health. OncoTargets and Therapy. 2024, 17: 395-409. doi: 10.2147/OTT.S456746.

3. Zhai SY, Gu HW, Wang C, Li YS*, Tang HB. Gynura procumbens and selected metabolites: Amelioration of depressive-like behaviors in mice and risperidone-induced hyperprolactinemia in rats. Biomed Pharmacother. 2024, 173: 116361. doi: 10.1016/j.biopha.2024.116361.

4. Yin X#, Li YS#, Ye SZ, Zhang T, Zhang YW, Xi Y, Tang HB. Promotion Effect of Coexposure to a High-Fat Diet and Nano-Diethylnitrosamine on the Progression of Fatty Liver Malignant Transformation into Liver Cancer. International Journal of Molecular Sciences. 2023, 24(18): 14162. doi: 10.3390/ijms241814162.

5. Meng SS, Gu HW, Zhang T, Li YS*, Tang HB. Gradual deterioration of fatty liver disease to liver cancer via inhibition of AMPK signaling pathways involved in energy-dependent disorders, cellular aging, and chronic inflammation. Frontiers in Oncology. 2023, 13: 1099624. doi: 10.3389/fonc.2023.1099624.

6. Yin X, Hong J, Tang HB, Liu M, Li YS*. Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil. Frontiers in Pharmacology. 2022, 13: 913098. doi: 10.3389/fphar.2022.913098.

7. Wang C, Huang XL, Mu YM, Li YS*, He YM, Tang HB. Synergistic effects of trans-p-coumaric acid isolated from the ethanol extract of Gynura procumbens in promoting intestinal absorption of chlorogenic acid and reversing alcoholic fatty liver disease. Journal of Ethnopharmacology. 2022, 295: 115407. doi: 10.1016/j.jep.2022.115407.

8. Zhang T, Gu HW, Gao JX, Li YS*, Tang HB. Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment. Journal of Ethnopharmacology. 2022, 285: 114917. doi: 10.1016/j.jep.2021.114917.

9. Li YS, Zhang J, Tian GH, Shang HC, Tang HB. Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration. Journal of Ethnopharmacology. 2021, 268: 113547. doi: 10.1016/j.jep.2020.113547.

10. Hong J, Chen XZ, Peng YG, Zhang WK, Tang HB, Li YS*. Nanoparticle-Encapsulated Liushenwan Could Treat Nanodiethylnitrosamine-Induced Liver Cancer in Mice by Interfering With Multiple Critical Factors for the Tumor Microenvironment. Frontiers in Pharmacology. 2020, 11: 1052. doi: 10.3389/fphar.2020.01052.

11. Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB, Li YS*, Zhang WK, Li XJ, Tian GH. E?ect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus. Brain Research. 2020, 1733: 146680. DOI: 10.1016/j.brainres.2020.146680.

12. Qin QF, Li XJ, Li YS*, Zhang WK, Tian GH, Shang HC, Tang HB. AMPK-ERK/CARM1 signaling pathways affect autophagy of hepatic cells in samples of liver cancer patients. Frontiers in Oncology. 2019, 9: 1247. DOI: 10.3389/fonc.2019.01247.

13. Huang XL, Li XJ, Qin QF, Li YS*, Zhang WK, Tang HB. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material. Journal of Ethnopharmacology. 2019, 239: 111916. DOI: 10.1016/j.jep.2019.111916.

14. Chen MT, Zhang WK, Liang WL, Li YS, Li XJ, Zhu LH, Tang HB. Controllable and extra-fast synthesis of bio-applicable silver nanoparticles with Lycium Barbarum L. Materials Technology. 2019, DOI: 10.1080/10667857.2019.1603656

15. Li XJ, Huang FZ, Wan Y, Li YS, Zhang WK, Xi Y, Tian GH, Tang HB. Lipopolysaccharide stimulated the migration of NIH3T3 Cells through a positive feedback between β-catenin and COX-2. Frontiers in Pharmacology. 2018, 9: 1487.

16. Qin QF, Liu M, Tian GH, Chen J, Li YS*. Extract of the blood circulation-promoting recipe-84 can protect rat retinas by inhibiting the beta-catenin signaling pathway. International Journal of Molecular Sciences. 2018, 19: 2712.

17. Chen XZ, Zhang WK, Tang HB, Li XJ, Tian GH, Shang HC, Li YS*. The ethanol supernatant extracts of Liushenwan could alleviate nanodiethylnitrosamine-induced liver cancer in mice. Canadian Journal of Gastroenterology and Hepatology. 2018, 2018: 6934809.

18. Zhang MT, Ye XX, Lan W, Yang YL, Wu T, Li YS*, Tang HB. Strategic combination of isocratic and gradient elution for simultaneous separation of polar compounds in traditional Chinese medicines by HPLC. Journal of Analytical Methods in Chemistry. 2018, 2018: 7569283.

三、近年主持或參與的國家自然科學基金項目

1. 基于β-catenin/COX-2炎性環(huán)路探究外用生膚油促進糖尿病足病快速修復的效應(yīng)機制，2021年國家自然科學基金面上項目；

2. 平臥菊三七干預“β-catenin/COX-2”炎性環(huán)路的防治肝癌機制研究. 2016年國家自然科學基金面上項目；

3. 電針對CPSP大鼠星形膠質(zhì)細胞介導的Wnt/β-catenin信號通路調(diào)控作用. 2016年國家自然科學基金面上項目

4. 六神丸干預“β-catenin與COX-2環(huán)路”的鎮(zhèn)癌痛機制研究. 2015年國家自然科學基金面上項目；

5. 基于Wnt/β-catenin靶點的益氣活血方抗糖尿病視網(wǎng)膜病變作用機制研究。2012年國家自然科學基金青年項目；

6. Wnt/β-catenin信號通路調(diào)控原發(fā)性肝癌發(fā)生的機制研究. 2011年國家自然科學基金青年項目；

7. 非神經(jīng)細胞對背根神經(jīng)節(jié)神經(jīng)細胞內(nèi)P物質(zhì)釋放的調(diào)控機制。2010年國家自然科學基金面上項目；