何 雋   （副教授/博士）

出生年月 ：1982.07

民族：漢

學科專業：藥物化學

研究方向：天然藥物化學

電子郵箱：2015048@mail.scuec.edu.cn

教育和工作簡歷：

1. 2021/1-至今，中南民族大學，藥學院，副教授，碩士生導師

2. 2015/7-2021/1，中南民族大學，藥學院，講師，碩士生導師

3. 2010/7-2015/6，中國科學院昆明植物研究所，植物化學與西部植物資源持續利用國家重點實驗室，助理研究員

4. 2005/9–2010/6，中國科學院昆明植物研究所，碩/博，藥物化學，博士

5. 2000/9–2004/7，西南大學，學士

研究方向：

傳統藥用植物及其內生菌化學成分與功能

學術研究

從事傳統藥用植物和植物內生菌功能性分子的發現，目前已經發現新的天然產物400余個，多個分子被評為研究熱點。主持國家自然科學基金、省部級項目等科研基金8項，在Org Lett，J Nat Prod等多種學術期刊以第一作者或通訊作者發表研究論文30余篇；獲授權專利2項。

（1）主要科研基金:

1. 國家自然科學基金面上項目，22177139、獼猴桃內生菌抑制其潰瘍病病原菌Psa的物質基礎及作用機制、63萬元、主持。

2. 國家自然科學基金青年科學基金項目，81102347、莢蒾屬植物萜類成分及其生物活性研究、20萬元、主持。

3. 湖北省自然科學基金項目，棕灰口蘑中“口蘑三萜”分子的發掘及其抗炎作用研究、3萬元、主持。

4. 校中央專項，CZY16010、藕帶的化學成分及生物活性研究、4萬元、主持。

5. 校中央專項，CZT18011、白堅木類生物堿的發掘研究、7萬元、主持。

6. NSFC-云南省聯合基金項目，U0932602、西南地區特有蕨類植物中先導化合物發現與作用機制研究、180萬元、核心成員。

（2）部分論著：

1. Jun-Jie Yu, Ying-Xue Jin, Shan-Shan Huang, Juan He*. Sesquiterpenoids and xanthones from the kiwifruit-associated fungus Bipolaris sp. and their anti-pathogenic microorganism activity. Journal of Fungi 2022, 8, 9.

2. Quan Dai, Fa-Lei Zhang, Zheng-Hui Li, Juan He*, Tao Feng*. Immunosuppressive sesquiterpenoids from the edible mushroom Craterellus odoratus. Journal of Fungi 2021, 7, 1052.

3. Juan He, Rui Ma, Zheng-Hui Li, Tao Feng*, and Ji-Kai Liu*. Taccachatrones A?G, highly oxidized steroids from the rhizomes of Tacca chantrierii and their cytotoxicity assessment. Journal of Natural Products 2021, 84, 2265?2271.

4. Jin-Tao Ma, Jiao-Xian Du, Yan Zhang, Ji-Kai Liu, Tao Feng, Juan He*. Natural imidazole alkaloids as antibacterial agents against Pseudomonas syringae pv. actinidiae isolated from kiwi endophytic fungus Fusarium tricinctum. Fitoterapia 2022, 156, 105070.

5. Juan He, Chao-Jun Pu, Meng Wang, Zheng-Hui Li, Tao Feng,* Da-Ke Zhao,* Ji-Kai Liu,* Conosiligins A?D, ring-rearranged tremulane sesquiterpenoids from Conocybe siliginea. J. Nat. Prod. 2020, 83, 2743?2748.

6. Yu Liang, Wen-Xuan Wang, Xing Wu, Meng Wang, Chao-Jun Pu, Zheng-Hui Li, Tao Feng, Juan He,* Ji-Kai Liu.* Panisuffrutin A, a highly degraded seco-triterpene derivative from Paeonia suffruticosa var. papaveracea (Andr.) Kerner. Tetrahedron Letters 2019, 60, 1838-1840.

7. Juan He, Fa-Lei Zhang, Zheng-Hui Li, Hui-Xiang Yang, Qian Shao, Tao Feng,* Ji-Kai Liu,* Monoterpenoid indole alkaloids from the bark of Melodinus henryi. Fitoterapia 2019, 138, 104354.

8. Juan He, Man-Si Yang, Wen-Xiang Wang, Zheng-Hui Li, Waill Ahmed Mohamed Elkhateeb, Ting-Chi Wen, Hong-Lian Ai*, Tao Feng*. Anti-phytopathogenic sesquiterpenoid-xanthoneadducts from potato endophytic fungus Bipolaris eleusines. RSC Advances 2019, 9, 128–131.

9. Wei Li¹, Juan He¹, Tao Feng*, Hui-Xiang Yang, Hong-Lian Ai, Zheng-Hui Li, Ji-Kai Liu*. Antroalbocin A, an antibacterial sesquiterpenoid from higher fungus Antrodiella albocinnamomea, Organic Letters 2018, 20, 8019–8021.

10. Tao Feng, Kai-Ting Duan, Shi-Jun He, Bin Wu, Yong-Sheng Zheng, Hong-Lian Ai, Zheng-Hui Li, Juan He, Jian-Ping Zuo, and Ji-Kai Liu, Ophiorrhines A and B, two immunosuppressive monoterpenoid indole alkaloids from Ophiorrhiza japonica. Organic Letters, 2018, 20, 7926–7928.

11. Xuan-Qin Chen, Li-Dong Shao, Mahesh Pal, Yu Shen, Xiao Cheng, Gang Xu, Li-Yan Peng, Kou Wang, Zheng-Hong Pan, Ming-Ming Li, Ying Leng, Juan He*, Qin-Shi Zhao*. Hupehenols A–E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense. Journal of Natural Products 2015, 78, 330?334.

12. Jin-Tang Cheng, Fei Liu, Xiao-Nian Li, Xing-De Wu, Liao-Bin Dong, Li-Yan Peng, Sheng-Xiong Huang, Juan He*, Qin-Shi Zhao* Lycospidine A, a new type ofLycopodium alkaloid from Lycopodium complanatum. Organic Letters 2013, 15, 2438-2441.

13. Gao Xiu, Li-Dong Shao, Liao-Bin Dong, Xiao Cheng, Xing-De Wu, Fei Liu, Wei-Wei Jiang, Li-Yan Peng, Juan He,* Qin-Shi Zhao.* Vibsatins A and B, two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. Variegatus. Organic Letters 2014, 16, 980?983.

14. Juan He, Li-Yan Peng, Lin Tu, Xing-De Wu, Liao-Bing Dong, Zheng-Hong Pan, Xuan-Qin Cheng, Jia Su, Yu Zhao, Gang Xu, Xiao Cheng, Yan Li, Qin-Shi Zhao*. Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissium. Fitoterapia 2016, 109: 224-229.

15. Juan He, Xuan-Qin Chen, Ming-Ming Li, Yu Zhao, Gang Xu, Xiao Cheng, Li-Yan Peng, Min-Jin Xie, Yong-Tang Zheng, Yi-Ping Wang, Qin-Shi Zhao* Lycojapodine A, a novel alkaloid from Lycopodium japonicum. Organic Letters 2009, 11, 1397-1400.

（3）授權專利：

何雋，艾洪蓮，李正輝，馮濤。蟋蟀草平臍蠕孢菌素I及其制備方法與應用、蟋蟀草平臍蠕孢菌素J及其制備方法與應用，發明專利，CN109503613B。