姓名：高超
職務/職稱：教授（碩/博導）
通訊地址：中南民族大學生命科學學院8號樓A502
E-mail：gaoc@scuec.edu.cn
一、研究領域和方向
目前在研的課題包括：
1、腎臟發育過程中的表觀遺傳調控。
2、慢性腎病致病的分子機制。
3、腎臟類器官構建。
二、教育背景
2010.09—2015.06，中國科學技術大學，生命科學學院，生物化學與分子生物學專業，博士
2005.09—2009.06，合肥工業大學，生物技術專業，理學學士
三、工作簡歷
2023.02—至今 中南民族大學生命科學學院，教授
2022.03—2022.10 美國奧爾巴尼醫學院，ResearchAssociate
2016.03—2022.02 美國奧爾巴尼醫學院，博士后
四、發表論文（*通訊作者）
1. Tsilosani A,Gao C, Chen E, Lightle A, Shehzad S, Sharma M, Tran P, Bates C, Wallace D, Zhang W. Pkd2 Deficiency in Embryonic Aqp2+ Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease.J Am Soc Nephrol. 2024;35(4):p 398-409. (IF 13.6)
2.Zhang W,Gao C, Tsilosani A, Samarakoon R, Plews R, and Higgins PJ. Potential renal stem/progenitor cells identified by in vivo lineage tracing.Am J Physiol Renal Physiol.2022;322(4):F379-F91.(IF 4.2)
3.Gao C, Zhang L, Chen E, and Zhang W. Aqp2(+) Progenitor Cells Maintain and Repair Distal Renal Segments.J Am Soc Nephrol.2022;33(7):1357-76.(IF 13.6)
4.Tsilosani A,Gao C, and Zhang W. Aldosterone-Regulated Sodium Transport and Blood Pressure.Front Physiol.2022;13:770375.(IF 4.755)
5.Gao C, Chen L, Chen E, Tsilosani A, Xia Y, and Zhang W. Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.J Am Soc Nephrol.2021;32(12):3035-49.(IF 13.6)
6.Heiserman JP, Nallanthighal S, Gifford CC, Graham K, Samarakoon R,Gao C, et al. Heat Shock Protein 27, a Novel Downstream Target of Collagen Type XI alpha 1, Synergizes with Fatty Acid Oxidation to Confer Cisplatin Resistance in Ovarian Cancer Cells.Cancers (Basel).2021;13(19).(IF 6.639)
7.Gao C, Higgins PJ, and Zhang W. AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions.Cells.2020;9(10).(IF 7.666)
8.Zhang L, Chen L,Gao C (joint first author), Chen E, Lightle AR, Foulke L, et al. Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2.J Am Soc Nephrol.2020;31(2):337-49.(IF 13.6)
9.Gao C, and Zhang W. Urinary AQP5 is independently associated with eGFR decline in patients with type 2 diabetes and nephropathy.Diabetes Res Clin Pract.2019;155:107805.(IF 8.18)
10.Chen L,Gao C (joint first author), Zhang L, Zhang Y, Chen E, and Zhang W. Highly tamoxifen-inducible principal cell-specific Cre mice with complete fidelity in cell specificity and no leakiness.Am J Physiol Renal Physiol.2018;314(4):F572-F83.(IF 4.2)
11.Gao C, Zhang L, Zhang Y, Wallace DP, Lopez-Soler RI, Higgins PJ, et al. Insights into cellular and molecular basis for urinary tract infection in autosomal-dominant polycystic kidney disease.Am J Physiol Renal Physiol.2017;313(5):F1077-F83.(IF 4.2)
12.Liu J,Gao C (joint first author), Chen W, Ma W, Li X, Shi Y, et al. CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation.Transl Psychiatry.2016;6(1):e703.(IF 7.989)
13.Ma W, Li C, Yin S, Liu J,Gao C, Lin Z, et al. Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in human hepatoma cells.Free Radic Biol Med.2015;89:1003-13.(IF 8.1)
14.Gao C, Yu Q, Xu H, Zhang L, Liu J, Jie Y, et al. Roles of the lateral fenestration residues of the P2X(4) receptor that contribute to the channel function and the deactivation effect of ivermectin.Purinergic Signal.2015;11(2):229-38.(IF 3.95)
15.Jie Y, Zhang L, Xu H,Gao C, Ma W, and Li Z. Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement.Neurosci Lett.2014;582:1-5.(IF 3.2)
16.Zhang L, Xu H, Jie Y,Gao C, Chen W, Yin S, et al. Involvement of ectodomain Leu 214 in ATP binding and channel desensitization of the P2X4 receptor.Biochemistry.2014;53(18):3012-9.(IF 3.321)
五、獲批專利
1.李志遠，高超，劉靜馨。一種快速增加細胞膜通透性的細胞內液及其方法。2018.06.19，中國，CN104911241B
